Journal: mSphere
Article Title: Bolaamphiphile Analogues of 12-bis-THA Cl 2 Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens
doi: 10.1128/msphere.00508-22
Figure Lengend Snippet: Bolalipids are protective in a G. mellonella model of E. coli ATCC 25922 infection. Survival curves over 72 h are plotted for 20 larvae, each treated with a single 10-mg/kg dose of Quino-bola (A), Penta-bola (B), Hepta-bola (C), or Octa-bola (D), in each case compared with 10 mg/kg CM2 or DQC or 2 mg/kg levofloxacin (LVX). Blue curves indicate significant protection according to a log rank (Mantel-Cox) test (CM2 P = 0.0527).
Article Snippet: Unlike with M. tuberculosis Bleupan, DQC was protective in G. mellonella against E. coli ATCC 25922 infection ( ).
Techniques: Infection